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CYTOCHROME-B(5) REDUCTASE
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DeCS
Descriptor
English
:
Cytochrome-B(5) Reductase
Descriptor
Spanish
:
Citocromo-B(5) Reductasa
Descriptor
Portuguese
:
Citocromo-B(5) Redutase
Tree Number:
D08.811.682.608.191.237
D12.776.331.186
Definition
English
:
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to
ALTERNATIVE SPLICING
of a single mRNA. The soluble form is present mainly in
ERYTHROCYTES
and is involved in the reduction of
METHEMOGLOBIN
. The membrane-bound form of the enzyme is found primarily in the
ENDOPLASMIC RETICULUM
and outer mitochondrial membrane, where it participates in the desaturation of
FATTY ACIDS
;
CHOLESTEROL
biosynthesis and drug
metabolism
. A deficiency in the enzyme can result in
METHEMOGLOBINEMIA.
Indexing Annotation
English
:
/defic: consider also
METHEMOGLOBINEMIA
History Note
English
:
2004; use CYTOCHROME B(5) REDUCTASE (NM) 1980-2003
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
38212
Unique Identifier:
D042966
Occurrence in VHL
:
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